Subjective Memory Complaint and Cognitive Aging

 
   Lead Investigator:    Katherine Gifford
   Institution      :    Vanderbilt
   E-Mail           :    katie.gifford@Vanderbilt.Edu
   Proposal ID      :    363


   Publications:


1  Gifford KA, Carmona H, Tripodis Y, Martin B, Cantwell N, Kowall N, Jefferson AL
   Subjective Cognitive Complaint Predicts Cognitive and Functional Trajectory in Individuals with Mild Cognitive Impairment
   2012   Abstract  Int'l Neuropsychological Society Meeting , 

   ACCEPTED



2  Gifford KA, Liu D, Lu Z, Carmona H, Romano R, Tripodis Y, Martin B, Kowall N, Jefferson AL
   Inclusion of an informant yields strong associations between cognitive complaint and longitudinal cognitive outcomes in non-demented elders
   Journal Article  J Alzheimers Dis,43:121-132,2015,PMC4314962

   PUBLISHED



3  Gifford KA, Liu D, Lu Z, Tripodis Y, Cantwell N, Palmisano J, Kowall N, Jefferson AL
   The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults
   Journal Article  Alzheimers Dement,10:319-327,2014,PMC4064681

   PUBLISHED



4  Tripodis Y, Palmisano J, Gentile A, Jefferson A
   Subjective Complaint and Cognitive Aging
   Abstract  Alzheimers Dement,7:S545,2011,

   PUBLISHED





   Proposal Description:
   This junior investigator study will provide better understanding of one of the qualitative factors related to MCI, subjective memory complaint, to refine the diagnostic criteria for MCI. Specifically, this project will identify how the cognitive, functional, and diagnostic trajectory of cognitive aging is impacted by the presence or absence of subjective complaint as reported by the individual or an informant. Using extant data from the National Alzheimer's Coordinating Center (NACC) data set, results from this research study will contribute to the literature with unique analyses aimed at enhancing the definition of subjective memory complaint as a predictor of abnormal cognitive   aging and associated functional changes seen early within the disease process.   Aim 1: Longitudinally examine how subjective and informant cognitive complaint among older adults free of dementia predict cognitive and functional trajectory over an expected mean 3-year follow-up period.   Aim 2: Compare baseline subjective and informant complaint for individuals with MCI at baseline who 1) revert back to normal cognition, 2) remain diagnostically, or 3) who convert to dementia over an expected mean 3-year follow-up period.